Columbia University in the City of New York · PharmacologyAbate-Shen Oncology Lab
Cory Abate-Shen · New York, New York
Research Focus
Dr. Cory Abate-Shen's research lab focuses on understanding the mechanisms of prostate cancer and bladder cancer progression. The lab employs advanced models, including genetically-engineered mice and patient-derived organoids, to investigate how specific genes and mitochondrial functions affect cancer development and metastasis. These studies aim to identify potential therapeutic targets for treatment.
prostate cancerbladder cancerNKX3.1BRCA1BRCA2mitochondrial dysfunctionagingDNA repairmetastasiscancer progression
Research Aims
5AIM 01Investigate the role of NKX3.1 in prostate cancer through its nuclear and mitochondrial functions.
AIM 02Examine the relationship between NKX3.1 loss and mitochondrial dysfunction in prostate cancer progression.
AIM 03Assess the functions of BRCA1 and BRCA2 in advanced prostate cancer and their role in DNA repair mechanisms.
AIM 04Identify master regulators of DNA repair pathways in prostate tumors.
AIM 05Utilize patient-derived organoids to study metastatic bladder cancer mechanisms.
Skills the Lab Values
cell culturemouse modelsgenetically engineered miceRNA sequencingorganoid cultureWestern blottingimmunohistochemistrybase editingcomputational modelingsingle-nuclei RNA sequencing
Output against the department
Publications357top 19% of dept.88th of 462
this lab
most publishedleast published
Citations16ktop 24% of dept.112th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.