University of California-Davis · Microbiology & ImmunologyHartigan-O'Connor Lab
Dennis J. Hartigan-O'Connor · Davis, California
Research Focus
Dr. Dennis J. Hartigan-O'Connor's lab at UC Davis focuses on understanding and improving treatments for HIV infection. The lab investigates how T-cell responses can be harnessed to develop effective vaccines that prevent and control HIV. By exploring the interactions between T-cells and antibodies, the lab aims to innovate new therapeutic approaches that could lead to lasting immune protection against HIV.
HIVvaccine developmentT-cell responsebroadly neutralizing antibodiestherapeutic vaccinationinfant macaquesimmune responseCD3/CCR5 bispecific antibody
Research Aims
4AIM 01Develop innovative HIV vaccine regimens that enhance T-cell and antibody responses.
AIM 02Investigate how T-cells can be effectively boosted for better immune responses in HIV treatment.
AIM 03Understand the role of bispecific antibodies in eliminating HIV reservoirs.
AIM 04Explore the metabolic conditions that enhance T-cell quality for HIV control.
Skills the Lab Values
cell cultureHIV infection modelsflow cytometryRNA sequencingmicroscopyanimal handling (macaques)PCRimmunohistochemistryvaccine formulation
Output against the department
Publications86bottom 28% of dept.349th of 486
this lab
most publishedleast published
Citations4.9kbottom 37% of dept.306th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.