WMCWeill Medical College of Cornell University · Physiology
Huang Lab
Xin-Yun Huang · New York, New York
Research Focus
Dr. Xin-Yun Huang's lab focuses on understanding the structural and regulatory mechanisms of the atrial natriuretic peptide receptor (ANPR), crucial for cardiovascular health. The research explores how this receptor regulates blood pressure and maintains cardiovascular balance, aiming to uncover insights that can lead to new therapies for heart diseases. By studying the interactions and conformational changes of the receptor, the lab is poised to contribute significantly to both basic science and clinical applications.
ANPcardiovascular homeostasisreceptor biologyhypertensioncGMP
Research Aims
3AIM 01Investigate the structural basis of GC-A activation by ANP.
AIM 02Explore the regulatory role of the kinase-homology domain on GC-A activity.
AIM 03Clarify the catalytic mechanism of GC-A and its operational catalytic sites.
Skills the Lab Values
protein purificationstructural biologymolecular dynamics simulationcryoelectron microscopybiochemical assays
Output against the department
Publications148bottom 49% of dept.147th of 286
this lab
most publishedleast published
Citations4.6kbottom 38% of dept.176th of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.