University of California-Irvine · BiochemistryTinoco T Cell Lab
Roberto Tinoco · Irvine, California
Research Focus
Roberto Tinoco's lab at UC Irvine focuses on understanding how specific proteins regulate T cell responses during chronic viral infections like HIV and HCV. The research aims to uncover the mechanisms by which T cells become exhausted and explore potential therapies to reinvigorate these immune cells. Overall, the lab seeks to enhance our understanding of T cell behavior and develop new treatment approaches for chronic infections and cancers.
T cell regulationviral infectionsmetabolic pathwaysimmune checkpoint blockadecellular metabolismchronic infectionsT cell exhaustiontherapeutic interventions
Research Aims
3AIM 01Determine the role of SAPS3 in virus-specific T cells during acute and chronic viral infection.
AIM 02Elucidate the molecular mechanisms by which SAPS3 regulates T cell activation.
AIM 03Evaluate the therapeutic potential of combining SAPS3 deletion and immune checkpoint blockade in resistant tumors.
Skills the Lab Values
cell culturemouse modelsflow cytometryWestern blotRNA sequencingimmunohistochemistryCRISPRdata analysis in immunologyimmunotherapy techniques
Output against the department
Publications57bottom 10% of dept.360th of 402
this lab
most publishedleast published
Citations2.7kbottom 13% of dept.349th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.