University of California-Los Angeles · Microbiology & ImmunologyNatural Killer Cell Research Unit
Timothy E O'Sullivan · Los Angeles, California
Research Focus
Dr. Timothy E. O'Sullivan's lab focuses on understanding how human natural killer (NK) cells function, especially in the context of viral infections like cytomegalovirus, which is particularly dangerous for newborns and immunocompromised individuals. By investigating the transcriptional regulators like MEF2C, the lab aims to develop strategies to enhance NK cell activity, potentially leading to new treatments for patients who are at high risk for these infections. This research combines molecular biology and immunology to improve health outcomes.
Natural Killer CellsCytomegalovirusTranscription FactorsCRISPRMetabolismImmunotherapyViral InfectionHuman HealthImmunocompromised Patients
Research Aims
3AIM 01Determine the transcriptional and post-translational mechanisms of MEF2C regulation in human NK cells.
AIM 02Evaluate the therapeutic efficacy of oleate supplementation on NK cell cytotoxicity.
AIM 03Investigate how the SREBP2 pathway promotes antiviral cytokine production in human NK cells.
Skills the Lab Values
CRISPR ScreeningCell CultureFlow CytometryChIP-seqRNA SequencingQuantitative PCRCell Proliferation AssaysCytokine Production AnalysisMouse ModelsBiological Assay Development
Output against the department
Publications66bottom 18% of dept.397th of 486
this lab
most publishedleast published
Citations3.8kbottom 28% of dept.349th of 486
this lab
most citedleast cited
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