University of Maryland, Baltimore · BiochemistryMedved Lab
Leonid V. Medved · Baltimore, Maryland
Research Focus
Dr. Leonid V. Medved's lab at the University of Maryland Baltimore focuses on the protein fibrinogen and its role in vital processes like inflammation and blood clotting. The lab investigates how interactions between fibrin and receptors on cells impact inflammation and angiogenesis—the formation of new blood vessels—which are critical in wound healing as well as in diseases like cancer. They aim to develop new therapies that could potentially treat conditions caused by these processes.
fibrinogeninflammationangiogenesisN-cadherintumorigenesisleukocyte transmigrationdrug development
Research Aims
4AIM 01Establish the structural basis for the fibrin-(N-cadherin) interaction.
AIM 02Test the hypothesis that N-cadherin is a receptor for the fibrin-derived 15-42 fragment.
AIM 03Investigate how the fibrin-(N-cadherin) interaction influences angiogenesis.
AIM 04Design novel inhibitors for the fibrin-(N-cadherin) interaction to reduce inflammation.
Skills the Lab Values
cell cultureanimal modelsprotein purificationWestern blotflow cytometrymolecular modelingin vitro assaysbiochemical assaysdrug design
Output against the department
Publications123bottom 34% of dept.265th of 402
this lab
most publishedleast published
Citations4.8kbottom 28% of dept.289th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.