Duke University · BiologySilva Ubiquitin Lab
Gustavo M Silva · Durham, North Carolina
Research Focus
Gustavo M Silva's lab at Duke University focuses on understanding how cells regulate the production of proteins during times of stress. By studying the role of ubiquitin, a small protein that marks others for degradation, the lab aims to unravel mechanisms that lead to diseases like neurodegeneration and cancer. Their research could help develop new strategies to improve health and combat stress-related conditions.
ubiquitinstress responsetranslation regulationneurodegenerative diseasesproteostasisoxidative stressribosome functionprotein expressionmolecular mechanismsdisease treatment
Research Aims
4AIM 01Investigate how ubiquitin modifications regulate ribosome function during stress.
AIM 02Determine the mechanisms by which ribosomes pause at specific mRNA sequences.
AIM 03Identify cofactors involved in redox regulation of ribosome activity.
AIM 04Explore the impact of ubiquitin on translation processes in human cells under stress.
Skills the Lab Values
molecular biologybiochemical assaysprotein purificationcell cultureproteomicsgenomic analysishigh-throughput screeningoxidative stress assaysdata analysis in biologycomputational biology
Output against the department
Publications37bottom 6% of dept.971st of 1,033
this lab
most publishedleast published
Citations1.3kbottom 8% of dept.951st of 1,033
this lab
most citedleast cited
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