University of Pennsylvania · NeuroscienceNeurodegenerative Disorders Research Lab
Corey T Mcmillan · Philadelphia, Pennsylvania
Research Focus
Dr. Corey T. McMillan's lab at the University of Pennsylvania focuses on understanding complex neurodegenerative disorders, specifically frontotemporal degeneration (FTD) and amyotrophic lateral sclerosis (ALS). The lab investigates how genetic variations influence the diversity in symptoms and progression of these diseases. Their work aims to identify new biomarkers and mechanisms that might help in the development of effective treatments, utilizing advanced imaging and genetic analysis techniques.
frontotemporal degenerationamyotrophic lateral sclerosisgenetic variationbiomarkersneurodegenerationTDP-43 proteinopathyneuropsychological traitsmedical imagingpolygenic risk scores
Research Aims
4AIM 01Identify biomarkers associated with frontotemporal degeneration and its symptoms.
AIM 02Investigate genetic modifiers that influence outcomes in ALS and FTD.
AIM 03Utilize multimodal data integration to enhance understanding of neurodegenerative diseases.
AIM 04Develop polygenic risk scores to predict cognitive and motor impairments in ALS-FTD patients.
Skills the Lab Values
genetic sequencingspatial transcriptomicscryogenic electron microscopyneuropsychological assessmentimaging techniques (MRI)data integrationbiostatisticstissue histologycell culture
Output against the department
Publications499top 11% of dept.74th of 671
this lab
most publishedleast published
Citations13ktop 32% of dept.217th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.