Oregon Health & Science University · Biomedical EngineeringRNA Degradosome Research Lab
Justin Merritt · Portland, Oregon
Research Focus
Dr. Justin Merritt's lab at Oregon Health & Science University explores the complex interactions of proteins in the bacteria Streptococcus mutans, which is closely linked to tooth decay. The research focuses on a unique protein complex called the RNA degradosome, which helps these bacteria manage gene regulation in response to their environment. By studying how different proteins work together within this complex, the lab aims to identify new therapeutic targets to reduce S. mutans levels and combat dental caries.
Streptococcus mutansRNA degradosomeposttranscriptional regulationprotein interactionsdental cariestherapeutic targetsbiofilm models
Research Aims
3AIM 01Investigate the role of moonlighting proteins in RNA regulation by the degradosome.
AIM 02Map the structural interactions within the degradosome and its targets.
AIM 03Assess the potential for therapeutic interventions targeting S. mutans protein interactions.
Skills the Lab Values
mass spectrometrynext-generation sequencingcryoelectron microscopygeneticsbioinformaticsbiochemical modelingmicrobial biofilmscell cultureprotein purification
Output against the department
Publications157bottom 34% of dept.388th of 595
this lab
most publishedleast published
Citations5.1kbottom 39% of dept.364th of 595
this lab
most citedleast cited
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