University of Pennsylvania · Microbiology & ImmunologyHIV Innovations and Therapeutics Lab
James L. Riley · Philadelphia, Pennsylvania
Research Focus
Dr. James L. Riley's lab is focused on innovative therapies for HIV, aiming to develop methods that can not only control but potentially cure the infection. They are working on advanced techniques, including engineered T cells and mRNA lipid nanoparticles, to deliver targeted treatments that can help remove the hidden reservoirs of the virus within the body. This research leverages cutting-edge immune engineering and cell therapy to improve patient outcomes for people living with HIV.
HIV cureCAR T cellsimmune engineeringmRNA lipid nanoparticlesviral reservoir
Research Aims
4AIM 01Develop targeted mRNA-lipid nanoparticles for delivering anti-HIV treatments.
AIM 02Explore engineering approaches to improve the effectiveness of CAR T cells in HIV patients.
AIM 03Investigate methods to reduce the viral reservoir in patients living with HIV.
AIM 04Evaluate the safety and efficacy of new therapies in clinical settings.
Skills the Lab Values
cell culturein vivo animal modelsgene editingflow cytometrymRNA technologyimmunoassayshumanized mouse modelstransfection techniquesprotein analysisT cell assays
Output against the department
Publications276top 19% of dept.90th of 486
this lab
most publishedleast published
Citations27ktop 12% of dept.58th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.