University of Pennsylvania · Biomedical EngineeringFan Glioblastoma Lab
Yi Fan · Philadelphia, Pennsylvania
Research Focus
Dr. Yi Fan's lab at the University of Pennsylvania focuses on understanding glioblastoma, a highly aggressive brain tumor, and how it resists treatments. The research aims to explore the role of specialized cells in the tumor's blood supply and their influence on the immune response, potentially paving the way for innovative therapies that could improve patient outcomes.
glioblastomavascularizationtherapy resistanceimmune responseendothelial plasticity
Research Aims
3AIM 01Define how endothelial FoxC2 contributes to abnormal blood vessel formation in tumors.
AIM 02Investigate the impact of FoxC2 on the function of immune T cells in glioblastoma.
AIM 03Evaluate new combined therapies targeting FoxC2 alongside traditional and immunotherapy treatments for brain tumors.
Skills the Lab Values
CRISPRsingle-cell RNA sequencingcell culturemouse modelsflow cytometryimmunotherapy techniquesgene editinglipid nanoparticle deliverytranscriptional analysistumor microenvironment studies
Output against the department
Publications127bottom 26% of dept.442nd of 595
this lab
most publishedleast published
Citations5.5kbottom 42% of dept.343rd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.