UWMUniversity of Wisconsin-Madison · Microbiology & Immunology
Botulinum Neurotoxin Research Lab
Sabine Pellett · Madison, Wisconsin
Research Focus
Dr. Sabine Pellett's lab at the University of Wisconsin-Madison focuses on understanding Botulinum Neurotoxins (BoNTs), which are potent toxins capable of causing severe disease. The lab investigates how these toxins work at a molecular level, especially regarding their duration and potency, which are crucial for both therapeutic applications and understanding their risks as potential bioweapons. Through innovative experimental approaches, the team aims to develop better treatments and countermeasures against botulism and related disorders.
Botulinum Neurotoxinsbioterrorismneuroparalytic diseasetherapeutic agentsmolecular mechanismsprotein toxinscell-based assaysneuromuscular disordersmRNA expression system
Research Aims
5AIM 01Identify the molecular mechanisms behind the potency of Botulinum Neurotoxins.
AIM 02Determine the duration of action of different BoNT serotypes in various cell types.
AIM 03Develop therapeutic variants of BoNTs to improve treatment efficacy for neuromuscular disorders.
AIM 04Investigate the trafficking and membrane association of Botulinum Neurotoxin light chains.
AIM 05Explore the potential of novel BoNTs in combatting botulism and related diseases.
Skills the Lab Values
mRNA expression techniquesmouse modelscell culturerecombinant protein productionmolecular cloningbiological assaysimmunological assaysdata analysis with Pythonbiostatistics
Output against the department
Publications113bottom 42% of dept.280th of 486
this lab
most publishedleast published
Citations3.7kbottom 27% of dept.355th of 486
this lab
most citedleast cited
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