Texas Tech University Health Sciences Center · Microbiology & ImmunologyLee Fungal Lab
Soo Chan Lee · Lubbock, Texas
Research Focus
Dr. Soo Chan Lee's lab at Texas Tech University Health Sciences Center focuses on understanding the mechanisms behind fungal infections, particularly mucormycosis caused by Mucorales fungi. The lab investigates how certain proteins, including calcineurin and protein kinase A, contribute to the virulence of these fungi and explores new strategies for antifungal drug development. By identifying specific genetic links and pathways in these organisms, the lab aims to provide insights that could lead to more effective treatments for life-threatening fungal infections in immunocompromised patients.
MucormycosisMucoralesCalcineurinProtein Kinase AFungal Drug ResistanceAntifungal Drug DevelopmentVirulence FactorsAmino Acid PermeasePathogenesisGene Regulation
Research Aims
3AIM 01Identify key transcription factor(s) regulated by calcineurin that affect amino acid permease expression.
AIM 02Elucidate the role of the amino acid permease in the virulence of Mucor.
AIM 03Demonstrate the genetic link between amino acid permease and protein kinase A.
Skills the Lab Values
Molecular cloningGenetic manipulationCell cultureProtein expression analysisWestern blottingGene expression assaysFlow cytometryFungal infection modelsTranscription factor analysisAntimicrobial susceptibility testing
Output against the department
Publications112bottom 41% of dept.285th of 486
this lab
most publishedleast published
Citations4.1kbottom 31% of dept.333rd of 486
this lab
most citedleast cited
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