University of Michigan-Ann Arbor · GeneticsIwase Lab
Shigeki Iwase · Ann Arbor, Michigan
Research Focus
The lab led by Dr. Shigeki Iwase focuses on understanding how chromatin modifications, specifically histone methylation, influence brain function and development. The research aims to uncover the specific roles that various enzymes play in synaptic plasticity and neurodevelopmental disorders such as autism and intellectual disabilities. By investigating the complex regulatory mechanisms in neurons, the lab hopes to develop new therapeutic strategies to address these disorders.
histone methylationneurodevelopmental disorderssynaptic plasticitychromatin regulationenzyme interaction
Research Aims
3AIM 01Investigate the roles of histone H3K4 methylation enzymes in synaptic scaling.
AIM 02Explore the molecular mechanisms behind the neuron-specific LSD1-PHF21A complex in gene regulation.
AIM 03Determine the structural differences between neuron-specific and canonical chromatin complexes.
Skills the Lab Values
chromatin immunoprecipitation sequencing (ChIP-seq)genome-wide methylation analysisbiochemical assaysfunctional genomicsneuroscience techniques
Output against the department
Publications79bottom 22% of dept.201st of 259
this lab
most publishedleast published
Citations4.8kbottom 25% of dept.194th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.