Thomas Jefferson University · BiochemistryPomerantz DNA Repair Lab
Richard T Pomerantz · Philadelphia, Pennsylvania
Research Focus
Dr. Richard T. Pomerantz leads a research lab at Thomas Jefferson University focused on DNA repair mechanisms, specifically those involving double-strand breaks and their implications in cancer therapy. His team's work includes developing targeted drugs for BRCA-deficient cancers and new treatments for diffuse large B-cell lymphoma (DLBCL). They utilize innovative strategies to improve existing therapies and explore previously unrecognized DNA repair pathways.
DNA repairBRCA-deficient cancersdouble-strand breaksnucleoside analogsdiffuse large B-cell lymphomamicrohomology-mediated end-joiningcancer therapyPol-Theta inhibitorschemical biologyRNA-DNA repair
Research Aims
5AIM 01Develop best-in-class Pol-Theta inhibitors for targeted cancer therapy.
AIM 02Investigate the roles of RNA in DNA double-strand break repair mechanisms.
AIM 03Characterize and develop a novel nucleoside analog for treating diffuse large B-cell lymphoma.
AIM 04Identify and optimize biomarkers for cancer treatment sensitivity.
AIM 05Explore undiscovered pathways in DNA double-strand break repair.
Skills the Lab Values
PCRcell cultureanimal modelsbiochemical assaysdrug designhigh-throughput screeningbiomarker characterizationin vivo efficacy testingmolecular cloningCRISPR
Output against the department
Publications94bottom 22% of dept.312th of 402
this lab
most publishedleast published
Citations2.6kbottom 12% of dept.355th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.