University of Minnesota-Twin Cities · BiologyAlzheimer's Genetic Models Lab
Michael D Koob · Minneapolis, Minnesota
Research Focus
Dr. Michael Koob's lab at the University of Minnesota focuses on developing advanced mouse models to better understand Alzheimer's Disease. By replacing mouse genes with their human counterparts, the lab aims to recreate the genetic and physiological aspects of Alzheimer's in a controllable laboratory setting. This research is important for identifying how specific genetic variations influence the disease and for developing new therapeutics.
Alzheimer's Diseasegene replacementhuman modelsmolecular mechanismstherapeutic targets
Research Aims
5AIM 01Develop human gene replacement mouse models to study Alzheimer's Disease.
AIM 02Evaluate the impact of specific human genetic variations on Alzheimer's risk.
AIM 03Investigate molecular disease mechanisms associated with Alzheimer's Disease.
AIM 04Produce mouse lines for the AD research community to study.
AIM 05Facilitate the identification of new therapeutic targets for Alzheimer's.
Skills the Lab Values
gene replacement techniquesmouse model generationgenomic sequencingPCRphenotypic evaluationmolecular biology techniquesbioinformaticsquality control proceduresexperimental designdata analysis
Output against the department
Publications82bottom 25% of dept.775th of 1,033
this lab
most publishedleast published
Citations3.2kbottom 24% of dept.788th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.