University of Rochester · NeuroscienceFrontal-Insular Network Research Group
Kuan Hong Wang · Rochester, New York
Research Focus
Dr. Kuan Hong Wang's lab at the University of Rochester focuses on understanding how aging and Alzheimer's disease affect a specific brain network called the frontal-insular network. They study the structural and functional changes in this network using advanced imaging techniques and mouse models. Their aim is to uncover the reasons behind cognitive decline in Alzheimer's and explore ways to improve cognitive function through targeted interventions.
Alzheimer's diseaseagingneurodegenerationfrontal-insular networkcognitive declinebehavioral flexibilitydopaminergic system
Research Aims
3AIM 01Determine age-related changes in the frontal-insular network in wild-type mice.
AIM 02Examine how genetic mutations associated with Alzheimer's disease accelerate degeneration in the frontal-insular network.
AIM 03Investigate molecular dysregulation in the frontal-insular network and test neuromodulation strategies to improve cognitive flexibility.
Skills the Lab Values
two-photon imagingfiber photometryspatial transcriptomicsoptogeneticspharmacogeneticsbehavioral assessmentsmouse modelsneuroscience research techniquescognitive flexibility tasks
Output against the department
Publications85bottom 26% of dept.497th of 671
this lab
most publishedleast published
Citations4.8kbottom 35% of dept.437th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.