University of Pennsylvania · BiologyExosome Dynamics Lab
Wei Guo · Philadelphia, Pennsylvania
Research Focus
Dr. Wei Guo's lab at the University of Pennsylvania focuses on understanding exosomes, which are tiny vesicles secreted by cells that play a crucial role in communication between cells. These exosomes carry molecules that can influence how other cells behave, impacting important processes such as cancer progression and immune responses. The lab investigates the mechanisms behind exosome secretion and how this process may be manipulated for therapeutic purposes, including potential cancer treatments.
exosomescell communicationtumor progressionimmune suppressionbiogenesissignaling moleculescancer therapydiagnostic biomarkers
Research Aims
5AIM 01Investigate how exosomes are formed and secreted by cells.
AIM 02Explore the role of signaling molecules in the regulation of exosome biogenesis.
AIM 03Understand the mechanisms through which exosomes affect immune responses.
AIM 04Study the influence of oncogenic signaling on exosome secretion in cancer.
AIM 05Develop potential therapeutic applications targeting exosome functions.
Skills the Lab Values
cell cultureWestern blotRNA sequencingbiochemistrymicroscopyimmunobiology techniquesbiological assaysmolecular cloning
Output against the department
Publications216top 29% of dept.301st of 1,033
this lab
most publishedleast published
Citations15ktop 26% of dept.266th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.