University of Pennsylvania · BiochemistryLynch Virology Lab
Kristen W Lynch · Philadelphia, Pennsylvania
Research Focus
Dr. Kristen W. Lynch's lab focuses on understanding how a specific protein kinase called TAO2 affects RNA processing and viral replication, particularly during Influenza virus infection. By exploring the interactions and functions of TAO2 in cellular environments, the lab aims to uncover new strategies for controlling viral infections and enhancing our understanding of RNA splicing mechanisms. This work combines genetics, biochemistry, and advanced imaging techniques to make significant implications for viral biology and cellular function.
TAO2RNA splicingInfluenza virusviral replicationnuclear speckles
Research Aims
3AIM 01Uncover how TAO2 regulates pre-mRNA splicing during Influenza virus infection.
AIM 02Characterize TAO2 interaction partners in the nucleus.
AIM 03Define the role of TAO2 in maintaining nuclear speckles and their function.
Skills the Lab Values
genetic manipulationbiochemistry techniquesmass spectrometrymicroscopyWestern blotting
Output against the department
Publications152bottom 43% of dept.231st of 402
this lab
most publishedleast published
Citations9.2kbottom 47% of dept.213th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.