University of California-Los Angeles · Social ScienceAllard Epigenetics Lab
Patrick Allard · Los Angeles, California
Research Focus
Dr. Patrick Allard's lab at UCLA focuses on how environmental chemicals, particularly arsenic, affect the epigenome, which is crucial for gene expression and development. The research aims to uncover how arsenic influences DNA methylation and histone modification, leading to heritable changes over generations. By studying mouse models, the lab hopes to shed light on the mechanisms behind these changes, which may have implications for understanding environmental impacts on health.
arsenicepigeneticsDNA methylationgerm cellsreprogrammingtransgenerational inheritancemetabolic enzymesenvironmental exposuremethyl donorshistone modification
Research Aims
5AIM 01Investigate how environmental arsenic exposure alters the epigenome.
AIM 02Examine the roles of specific metabolic enzymes in epigenetic changes.
AIM 03Assess the heritability of epigenetic modifications through generational studies.
AIM 04Explore the reprogramming resistance of epimutations in germ cells.
AIM 05Determine the impact of arsenic-induced metabolic changes on DNA and histone modifications.
Skills the Lab Values
ChIP-seqRNA sequencingwhole genome bisulfite sequencingcell culturemouse modelstranscriptional analysisbioinformaticsmetabolomicsgenetic transcriptionchromatin analysis
Output against the department
Publications227top 29% of dept.22nd of 77
this lab
most publishedleast published
Citations8.2ktop 27% of dept.21st of 77
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.