Texas A&M University-College Station · BiologyColorectal Recovery Lab
Stephen H. Safe · College Station, Texas
Research Focus
In Dr. Stephen H. Safe's lab at Texas A&M University, researchers focus on developing new treatments for colorectal cancer. They study a specific receptor, NR4A1, which is found in high levels in colon cancer patients and is linked to tumor growth and immune system suppression. By using innovative compounds known as CDIMs, the team aims to create drugs that can both fight cancer and help improve the immune response against tumors.
colorectal cancerNR4A1immunotherapychemotherapydrug development
Research Aims
4AIM 01Investigate the mechanisms of NR4A1 antagonists in colon cancer cells.
AIM 02Assess the effects of CDIMs on immune response in mouse models.
AIM 03Analyze tumor microenvironment interactions using histology.
AIM 04Explore the therapeutic potential of bis-indole derived agents in cancer treatment.
Skills the Lab Values
cell culturemouse modelsdrug screeninghistological analysissingle cell analysis
Output against the department
Publications1,254top 1% of dept.8th of 1,033
this lab
most publishedleast published
Citations67ktop 2% of dept.25th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.