Washington University in St Louis · EngineeringGuan Regeneration Lab
Jianjun Guan · Saint Louis, Missouri
Research Focus
Dr. Jianjun Guan's research lab focuses on innovative methods to improve heart function and limb regeneration following ischemic injury. They are particularly interested in delivering specialized proteins and nanoparticles that can control inflammation and promote healing in damaged tissues, especially after heart attacks and in diabetic patients suffering from critical limb ischemia. The lab combines engineering techniques with biological insights to design therapies that ideally target the areas of injury and improve recovery outcomes.
nanoparticlesinflammationfibrosismyocardial infarctiondiabetic ischemic limbsangiogenesisgrowth factor therapyprotein deliverytissue regenerationcardiac repair
Research Aims
5AIM 01Develop nanoparticles that target the heart post-myocardial infarction
AIM 02Engineer a protein to enhance survival of cells in diabetic conditions
AIM 03Test the release efficiency of therapeutic agents from nanoparticles
AIM 04Evaluate the dual role of proteins in reducing inflammation and promoting healing
AIM 05Investigate the optimal composition of M2 macrophage secretome for cardiac therapy
Skills the Lab Values
cell culturenanoparticle designengineered protein synthesisintravenous injectionsanimal modelsimmunohistochemistrymolecular cloningtherapeutic protein characterizationflow cytometrydrug formulation
Output against the department
Publications176bottom 44% of dept.154th of 278
this lab
most publishedleast published
Citations10ktop 37% of dept.102nd of 278
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.