University of Rochester · PharmacologyKammermeier Lab
Paul J. Kammermeier · Rochester, New York
Research Focus
Dr. Paul Kammermeier's lab at the University of Rochester studies metabotropic glutamate receptors (mGluRs), which are important proteins involved in brain signaling. The lab focuses on how these receptors interact with each other in pairs called dimers, particularly the differences between their homodimers and heterodimers. By developing new methods to isolate and study specific mGluR dimers, the lab aims to create a detailed atlas that will help in designing better drugs for various brain-related disorders.
mGluRheterodimerizationbrain signalingpharmacologytherapeutics
Research Aims
3AIM 01Build and characterize tagged mGluRs using a novel dimer composition control system.
AIM 02Obtain heterodimer specific G protein recruitment data using an adapted CODA-RET approach.
AIM 03Assess the pharmacological responses of mGluR dimer pairs to various ligands.
Skills the Lab Values
cell culturemolecular cloningelectrophysiologyprotein expressionligand binding assays
Output against the department
Publications71bottom 15% of dept.392nd of 462
this lab
most publishedleast published
Citations1.7kbottom 10% of dept.414th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.