Ohio State University-Main Campus · PhysiologyThe Calmodulin Nexus
Sandor Gyorke · Columbus, Ohio
Research Focus
Dr. Sandor Gyorke's lab focuses on understanding how a calcium-binding protein called calmodulin regulates heart function. They study how calmodulin is produced from three different genes and how this complexity contributes to precise signaling in heart cells. This research has implications for developing targeted therapies for cardiovascular diseases.
CalmodulinCardiac MyocytesCalcium SignalingRNA Binding ProteinsCardiovascular DiseasesProtein EngineeringTranslational ControlImaging Techniques
Research Aims
5AIM 01Investigate the role of calmodulin in cardiac myocyte function.
AIM 02Define the distribution and translation sites of calmodulin mRNAs in heart cells.
AIM 03Explore the interaction of calmodulin with its protein targets in health and disease.
AIM 04Develop imaging tools to visualize calmodulin-mediated signaling processes.
AIM 05Apply findings to engineer therapeutic proteins targeting specific pathways.
Skills the Lab Values
Molecular Biology TechniquesImmunofluorescence MicroscopyData Analysis Software DevelopmentRNA SequencingCell CultureSubcellular Localization TechniquesElectrophysiologyProtein Expression and Purification
Output against the department
Publications277top 20% of dept.56th of 286
this lab
most publishedleast published
Citations10ktop 33% of dept.93rd of 286
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.