Creighton University · Microbiology & ImmunologyPrion Dynamics Research Group
Jason C Bartz · Omaha, Nebraska
Research Focus
Dr. Jason Bartz's lab focuses on understanding prions, which are infectious proteins that can cause diseases and evolve rapidly when they infect new host organisms. The research investigates how different strains and substrains of prions contribute to their ability to transmit between species and adapt to new environments. By studying these dynamics, the lab aims to improve treatment strategies for prion-related diseases and prevent their spread.
prionszoonotic diseasesstrain dynamicstransmissible mink encephalopathychronic wasting disease
Research Aims
5AIM 01Explore the frequency and diversity of prion substrains from stable and unstable strains.
AIM 02Investigate interspecies transmission of prion strains using hamster/mouse models.
AIM 03Test the hypothesis that prion substrains drive transmission to new PrP genotypes.
AIM 04Assess the impact of drug treatment on prion strain evolution.
AIM 05Examine strain interference during prion transmission processes.
Skills the Lab Values
animal bioassaysin vitro prion detectionprotease digestionthermostability testingbioinformatics analysis
Output against the department
Publications133top 48% of dept.232nd of 486
this lab
most publishedleast published
Citations3.9kbottom 29% of dept.346th of 486
this lab
most citedleast cited
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