University of Maryland, Baltimore · Biomedical EngineeringCancer Therapeutics and Resistance Unit
France Carrier · Baltimore, Maryland
Research Focus
Dr. France Carrier's lab at the University of Maryland Baltimore focuses on developing innovative cancer therapies that combine small molecules to target key cellular pathways involved in cancer progression and immune evasion. The research aims to create less toxic treatments that can more effectively combat drug resistance in various cancers. The team employs a mix of medicinal chemistry, structural biology, and cancer biology to create and test these new therapeutic agents.
cancer therapysmall moleculesimmune checkpointprotein translationdrug resistancehnRNP A18therapeutic inhibitorsprecision medicine
Research Aims
3AIM 01Design and synthesize small molecule inhibitors of hnRNP A18.
AIM 02Prioritize compounds through in vitro testing for efficacy and toxicity.
AIM 03Evaluate the anti-tumor properties of lead compounds in animal models.
Skills the Lab Values
medicinal chemistrystructural biologycell culturein vitro assaysmouse modelsRNA binding assaysdrug designxenograft modelspatient derived xenograft (PDX) models
Output against the department
Publications97bottom 17% of dept.496th of 595
this lab
most publishedleast published
Citations7.9ktop 44% of dept.262nd of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.