Icahn School of Medicine at Mount Sinai · PharmacologyYuen Neurobiology Lab
Tony Yuen · New York, New York
Research Focus
Dr. Tony Yuen's lab at the Icahn School of Medicine focuses on understanding how certain hormones affect brain health, particularly in relation to Alzheimer's disease in postmenopausal women. They are developing new tools to target and study the role of a hormone called follicle-stimulating hormone (FSH) in the brain, and how reducing its receptor can help alleviate memory loss and other cognitive issues associated with aging. Their research combines advanced genetic techniques and innovative viral delivery methods to explore potential treatments for these conditions.
Alzheimer's diseasefollicle-stimulating hormonebrain receptorsgene therapyAAV vectorsagingmemory losscognitionneurodegeneration
Research Aims
5AIM 01Investigate the role of follicle-stimulating hormone in Alzheimer's disease
AIM 02Develop adeno-associated viral vectors for targeted gene delivery
AIM 03Assess the impact of FSH receptor knockdown on cognitive function in mice
AIM 04Explore cellular mechanisms linking FSH to neurodegeneration
AIM 05Lay groundwork for potential therapeutic strategies against aging-related cognitive decline.
Skills the Lab Values
AAV constructiongene knockdown techniquesimmunohistochemistryanimal handling and experimentation (mouse models)molecular cloningin vivo imagingcell culturebehavioral assaysconstructing plasmidsNeuroscience research methods
Output against the department
Publications208top 42% of dept.194th of 462
this lab
most publishedleast published
Citations8.4ktop 45% of dept.206th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.