University of Virginia-Main Campus · Microbiology & ImmunologyDerre Pathogenesis Lab
Isabelle Derre · Charlottesville, Virginia
Research Focus
Dr. Isabelle Derre's lab focuses on understanding Chlamydia trachomatis, a major cause of sexually transmitted infections. The team investigates how this bacterium maintains its environment for replication and affects women's reproductive health. By studying the specific proteins involved in lipid acquisition, they aim to identify new ways to create effective therapies and prevent infections.
Chlamydialipid acquisitionpathogenesissexually transmitted infectionsreproductive healththerapeuticsvaccine development
Research Aims
5AIM 01Investigate how Chlamydia acquires and maintains lipids essential for its replication.
AIM 02Characterize the role of specific inclusion membrane proteins in Chlamydia pathogenesis.
AIM 03Explore the link between sphingolipid trafficking and the integrity of the bacterial replicative niche.
AIM 04Identify potential therapeutic targets among Chlamydia-specific proteins to aid in vaccine development.
AIM 05Assess how Chlamydia infections lead to complications in women's reproductive health.
Skills the Lab Values
cell cultureanimal modelsgenetic screeningprotein characterizationmicroscopyimmune response assaysbiological assayslipid metabolism techniquesdata analysis using Python
Output against the department
Publications50bottom 11% of dept.430th of 486
this lab
most publishedleast published
Citations3.1kbottom 22% of dept.379th of 486
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.