Clemson University · Biomedical EngineeringCardiac Organoid Engineering Lab
Ying Mei · Clemson, South Carolina
Research Focus
Dr. Ying Mei's lab at Clemson University focuses on using advanced materials to develop innovative treatments for heart repair, specifically targeting cardiovascular diseases. The research primarily involves creating human heart organoids from stem cells, enhanced with silicon nanowires for better function and survival after implantation. By exploring hypoimmunogenic properties, the lab aims to produce organoids that can be used as off-the-shelf therapies for patients who have suffered heart injuries.
cardiac organoidshuman pluripotent stem cellsnanowireshypoimmunogenicitycardiovascular diseasetissue engineeringheart repairbiomaterialspseudohypoxia
Research Aims
3AIM 01Develop silicon nanowire-enhanced cardiac organoids for improved engraftment and function.
AIM 02Investigate the effects of gene editing on stem cell-derived cardiac cells.
AIM 03Study the therapeutic efficacy of engineered cardiac organoids in animal models.
Skills the Lab Values
cell culturestem cell differentiationsilicon nanowire engineeringsurgical implantationin vivo modelshypoxia-inducible factor modulationgene editing techniquescardiac function assessmentelectrophysiology testing
Output against the department
Publications269top 36% of dept.212th of 595
this lab
most publishedleast published
Citations9.8ktop 35% of dept.209th of 595
this lab
most citedleast cited
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