UMCUniversity of Massachusetts Chan Medical School · Biology
Mitochondrial Insights Lab
Cole M Haynes · Worcester, Massachusetts
Research Focus
Dr. Cole Haynes' lab focuses on understanding how cells generate and maintain mitochondrial networks, especially as they relate to aging and age-related diseases like Alzheimer's and Parkinson's. By studying a specific transcription factor, ATFS-1, the lab aims to uncover the mechanisms that control mitochondrial function and biogenesis during development and throughout an organism's life. This research could help develop strategies for improving mitochondrial health in aging populations.
mitochondrial functionagingAlzheimer's diseaseParkinson's diseaseATFS-1mitochondrial biogenesistranscription factorcell developmenthealth span
Research Aims
5AIM 01Investigate how ATFS-1 regulates mitochondrial mass during development.
AIM 02Explore the role of the mitochondrial unfolded protein response in aging.
AIM 03Understand the impact of mitochondrial dysfunction on cellular health.
AIM 04Determine if mitochondrial genome replication is linked to cell growth physiology.
AIM 05Evaluate strategies to promote mitochondrial network maintenance.
Skills the Lab Values
cell culturemolecular cloningWestern blotRNA sequencingmicroscopyanimal modelsCRISPRdata analysisbiostatisticsgene expression analysis
Output against the department
Publications94bottom 32% of dept.701st of 1,033
this lab
most publishedleast published
Citations16ktop 24% of dept.249th of 1,033
this lab
most citedleast cited
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