University of Southern California · BiochemistryArnold Lab
Donald B Arnold · Los Angeles, California
Research Focus
Dr. Donald B. Arnold's lab focuses on developing innovative methods to trace and study neural circuits in the brain. Their work aims to understand how neural connections change during development, learning, and disease by using advanced techniques for tracking both excitatory and inhibitory neurons. The research has significant implications for mapping brain function and could aid in addressing various neurological conditions.
neural circuitsanterograde tracinginhibitory neuronscholinergic circuitstransgenic techniquesgenetic labelingneurosciencebrain mappingactivity-dependent tracing
Research Aims
5AIM 01Develop a method for anterograde tracing from genetically determined inhibitory neurons.
AIM 02Create tracers for labeling cholinergic circuits in the brain.
AIM 03Investigate changes in neural connections during learning and disease.
AIM 04Assess the activity-dependent characteristics of new neurochemical tracers.
AIM 05Make novel methods available for mapping neural circuitry in live subjects.
Skills the Lab Values
PCRgene editing techniquestransgenic animal modelsoptogeneticsimmunohistochemistryelectrophysiologycell cultureWestern blottingfluorescence microscopy