University of California-Irvine · BiochemistryThe Immune Nexus Lab
Ivan Marazzi · Irvine, California
Research Focus
Dr. Ivan Marazzi's lab at UC Irvine focuses on understanding how inflammation affects disease responses during infections and in neurodegenerative conditions like ALS. Their current projects explore how the immune system, particularly certain T cells, influences the severity of COVID-19 and a rare juvenile form of motor neuron disease. The lab aims to develop therapeutic strategies based on their findings to better manage these diseases.
SARS-CoV-2inflammationT cell immunityamyotrophic lateral sclerosisepigeneticsgene regulationimmune responsetopoisomerase inhibitorsneurodegeneration
Research Aims
5AIM 01Characterize the role of Top1 and epigenetic factors in regulating inflammatory gene expression during SARS-CoV-2 infection.
AIM 02Test the effectiveness of Top1 inhibitors in animal models of COVID-19.
AIM 03Investigate how CD8 T cells contribute to the progression of ALS4.
AIM 04Determine the molecular pathways involved in neuro-immune interactions in ALS.
AIM 05Validate the presence of activated CD8 T cells in ALS patients.
Skills the Lab Values
PCRcell culturemouse modelsRNA sequencingflow cytometryimmunohistochemistrybiochemical assaysnetwork modelingstatistical analysis
Output against the department
Publications77bottom 15% of dept.341st of 402
this lab
most publishedleast published
Citations5.5kbottom 32% of dept.275th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.