University of Minnesota-Twin Cities · BiochemistryProtein Kinase A Research Unit
Gianluigi Veglia · Minneapolis, Minnesota
Research Focus
Dr. Gianluigi Veglia's lab at the University of Minnesota focuses on understanding the molecular basis of diseases linked to mutations in the PRKACA gene, which is crucial for regulating various cellular processes. By studying how specific mutations affect the function of protein kinase A (PKA-C), the lab aims to uncover mechanisms that may lead to conditions like Cushing's syndrome and certain types of cancer. They employ advanced techniques to analyze protein behavior in hopes of finding targeted therapies to correct these dysfunctions.
protein kinase ACushing syndromecancer geneticsmolecular mechanismsbiophysics
Research Aims
5AIM 01Characterize the impact of mutations in the PRKACA gene on PKA-C function.
AIM 02Investigate how misregulated PKA-C activity contributes to disease progression.
AIM 03Identify potential therapeutic strategies targeting dysfunctional enzymatic activity.
AIM 04Explore allosteric interactions within PKA-C regulatory complexes.
AIM 05Assess the molecular mechanisms behind specific endocrine-related diseases.
Skills the Lab Values
liquid-state NMRbiochemical assaysbiophysical characterizationmutagenesiscell culture
Output against the department
Publications363top 15% of dept.61st of 402
this lab
most publishedleast published
Citations9.8ktop 50% of dept.199th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.