Augusta University · BiochemistryImmunotherapy and T-Cell Dynamics Lab
Gang Zhou · Augusta, Georgia
Research Focus
Dr. Gang Zhou's lab at Augusta University focuses on enhancing immunotherapy techniques, particularly adoptive T-cell therapy (ACT). The lab investigates how specific signaling pathways can be manipulated to improve the ability of CD4 T cells to fight cancers, especially by promoting their persistence and multifunctionality. Their research aims to develop new approaches that could make ACT more effective for solid tumors, potentially leading to better patient outcomes.
adoptive T cell therapyCD4 T cellsSTAT5 signalingimmunotherapycancer treatmentCAR T cellsepigeneticscytokine productiontumor immunity
Research Aims
3AIM 01Investigate how persistent STAT5 signaling induces and maintains polyfunctional CD4 T cells.
AIM 02Evaluate the impact of CASTAT5-induced polyfunctional CD4 T cells on enhancing adoptive T cell therapy.
AIM 03Explore the potential application of CASTAT5 in improving human CD19 CAR T cells.
Skills the Lab Values
cell culturegene expression analysisCRISPR/Cas9single-cell RNA sequencingepigenomic analysisin vitro experimentsflow cytometryanimal modelsdata analysis using bioinformatics
Output against the department
Publications161bottom 45% of dept.220th of 402
this lab
most publishedleast published
Citations1.1kbottom 3% of dept.389th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.