University of North Carolina at Chapel Hill · GeneticsGenetic Exchange and Stability Lab
Jeff J. Sekelsky · Chapel Hill, North Carolina
Research Focus
Dr. Jeff Sekelsky's lab at UNC Chapel Hill studies how genetic information is exchanged in cells during processes like meiosis and mitosis. They aim to understand the balance between promoting accurate gene segregation, which is crucial for healthy reproduction, and preventing harmful genome changes that can lead to cancer. Using techniques from genetics to molecular biology, the lab explores the mechanisms that influence these processes and how they can be applied to gene editing technologies like CRISPR.
meiosismitosisgenetic recombinationgenome stabilityCRISPRhistone modificationsDNA repairDrosophila geneticschromosome segregation
Research Aims
5AIM 01Investigate mechanisms promoting crossovers in meiotic cells.
AIM 02Study the non-crossover outcomes of DNA repair in mitotic cells.
AIM 03Examine the roles of histone modifications in recombination processes.
AIM 04Explore the patterns of meiotic crossover formation.
AIM 05Assess DNA double-strand break repair mechanisms in experimental settings.
Skills the Lab Values
genetic sequencingDrosophila geneticsmicroscopybiochemical assayscell culturemolecular cloningmathematical modelinggene editing (CRISPR)flow cytometry
Output against the department
Publications155top 50% of dept.130th of 259
this lab
most publishedleast published
Citations5.5kbottom 31% of dept.180th of 259
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.