University of Washington-Seattle Campus · NeuroscienceWeinstein Microglia Lab
Jonathan R Weinstein · Seattle, Washington
Research Focus
Dr. Jonathan R Weinstein's lab at the University of Washington focuses on understanding the role of microglia, which are the brain's immune cells, in chronic cerebrovascular diseases and cognitive impairment. By using advanced mouse models and imaging techniques, the lab investigates how microglial signaling drives white matter damage associated with conditions like dementia. The ultimate goal is to identify new diagnostics and treatment strategies that could improve outcomes for patients suffering from vascular cognitive impairment.
microgliacerebral small vessel diseasevascular cognitive impairmentneuroinflammationtransgenic mouse modelsneuroimagingbiomarker developmentcognitive dysfunction
Research Aims
5AIM 01Investigate the role of microglia in the development of cerebral small vessel disease.
AIM 02Evaluate the effects of gliotransmitter signaling on cognitive functions.
AIM 03Identify potential biomarkers for neuroinflammation using novel imaging techniques.
AIM 04Assess the impact of specific pharmacological treatments on white matter integrity.
AIM 05Explore the genetic factors influencing microglial function in cerebrovascular diseases.
Skills the Lab Values
single cell RNA sequencing2-photon imagingdiffusion tensor imagingmagnetic resonance imaging (MRI)positron emission tomography (PET)genetic manipulationpharmacological treatmentslongitudinal studiesbioinformaticsdata analysis
Output against the department
Publications56bottom 13% of dept.582nd of 671
this lab
most publishedleast published
Citations1.8kbottom 11% of dept.598th of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.