University of Florida · GeneticsHIV Therapy Innovation Lab
Susana T Valente · Gainesville, Florida
Research Focus
Dr. Susana Valente's research lab at the University of Florida focuses on developing innovative therapies to combat HIV. The lab is particularly interested in transcriptional inhibitors, which can potentially silence the virus without ongoing therapy, aiming for a functional cure. By exploring various compounds and their effects on HIV transcription, the lab seeks to reduce inflammation and improve the quality of life for people living with HIV.
HIV transcriptionTat inhibitorsHIV therapyblock-and-lockHIV functional cureSpironolactonedidehydro-Cortistatin Aviral latencyimmunologydrug discovery
Research Aims
5AIM 01Investigate the effect of Spironolactone on HIV transcription in humanized mice.
AIM 02Evaluate the potential of didehydro-Cortistatin A as a single agent for blocking HIV reactivation.
AIM 03Explore the combined efficacy of Spironolactone and didehydro-Cortistatin A in reducing viral reservoirs.
AIM 04Develop novel Tat inhibitors through medicinal chemistry techniques.
AIM 05Assess the impact of HIV transcriptional inhibition on chronic immune activation.
Skills the Lab Values
cell culturehigh-throughput screeningmouse modelsdrug repurposingmolecular dynamicsbiological assaystranscription analysisimmune response assessmentmedicinal chemistrytherapeutic index evaluation
Output against the department
Publications73bottom 19% of dept.208th of 259
this lab
most publishedleast published
Citations2.4kbottom 11% of dept.230th of 259
this lab
most citedleast cited
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