Yale University · NeuroscienceNeuroinflammation and Cell Interaction Lab
Jaime Grutzendler · New Haven, Connecticut
Research Focus
Dr. Jaime Grutzendler's lab focuses on understanding how two types of brain cells, microglia and astrocytes, interact in the context of Alzheimer's disease. The lab is investigating the protective roles these cells may play in wrapping around amyloid plaques, which are harmful clumps found in the brains of Alzheimer's patients. By using advanced imaging techniques, the researchers aim to uncover cellular interactions that could lead to new therapeutic strategies to protect neurons in Alzheimer's disease.
Alzheimer's diseasemicrogliaastrocytesneuroprotectionamyloid plaquescell signalinglive imaginghigh-resolution microscopyin vivo studiesneural dysfunction
Research Aims
5AIM 01Investigate the protective role of microglia in Alzheimer's disease.
AIM 02Study the interaction between microglia and astrocytes during amyloid plaque encapsulation.
AIM 03Explore molecular pathways that enhance glial protection.
AIM 04Utilize advanced imaging techniques to visualize cellular processes.
AIM 05Identify potential therapeutic targets to reduce axonal damage in Alzheimer's.
Skills the Lab Values
super-resolution imagingin vivo optical imaginggenetic manipulationhigh-resolution microscopymouse modelsCRISPR/Cas technologydata analysismolecular biology techniquesimmunohistochemistryneuroanatomy
Output against the department
Publications109bottom 38% of dept.417th of 671
this lab
most publishedleast published
Citations16ktop 25% of dept.171st of 671
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.