University of Vermont · PharmacologyThe Aldosterone Impact Lab
Masayo Koide · Burlington, Vermont
Research Focus
Dr. Masayo Koide's lab studies how high levels of the hormone aldosterone can negatively affect small blood vessels in the brain, potentially leading to cognitive issues or dementia. The research focuses on understanding the mechanisms by which this hormone impacts blood flow in very small brain vessels and aims to identify new ways to protect brain health. This work is important for developing strategies to mitigate cognitive decline associated with small vessel diseases.
aldosteronecognitive impairmentsmall blood vesselsvascular functiondementia
Research Aims
3AIM 01Investigate the role of aldosterone in small vessel dysfunction in the brain.
AIM 02Evaluate how aldosterone affects blood flow regulation in brain capillaries.
AIM 03Assess the impact of aldosterone on cognition-related brain areas.
Skills the Lab Values
mouse modelsmolecular biology techniquesRNA sequencingpatch-clamp electrophysiologyin vivo imaging techniques
Output against the department
Publications95bottom 23% of dept.354th of 462
this lab
most publishedleast published
Citations2.4kbottom 17% of dept.383rd of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.