University of California-Davis · PhysiologyFolate Development Lab
Laura Noemi Borodinsky · Davis, California
Research Focus
Dr. Laura Noemi Borodinsky's lab at UC Davis studies how folate, a vital vitamin, influences the development of the nervous system. Her research particularly focuses on understanding the molecular mechanisms behind neural tube defects, which occur when the neural tube, a critical structure in early fetal development, fails to close properly. By examining how folate interacts with specific proteins during this developmental process, her team aims to uncover insights that could lead to better prevention and treatment strategies for these serious birth defects.
FolateNeural Tube DefectsNeural DevelopmentApical EndocytosisSignal TransductionXenopus laevisStem Cell ModelsCalcium DynamicsCell SignalingCongenital Abnormalities
Research Aims
5AIM 01Investigate the role of folate in neural tube formation.
AIM 02Understand the interaction between FOLR1 and CD2AP in neural development.
AIM 03Identify signaling mechanisms that are activated by folate during embryogenesis.
AIM 04Explore the effects of folate on calcium dynamics in neural plate cells.
AIM 05Develop strategies to prevent folate-sensitive neural tube defects.
Skills the Lab Values
Xenopus laevis embryologyCell culture techniquesCo-immunoprecipitationMolecular profilingFluorescence microscopySignal pathway analysisGenetic screeningNeural organoid modelsCalcium imagingWestern blotting
Output against the department
Publications60bottom 10% of dept.257th of 286
this lab
most publishedleast published
Citations2.2kbottom 14% of dept.246th of 286
this lab
most citedleast cited
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