University of Washington-Seattle Campus · Biomedical EngineeringMarcinek Lab
David J. Marcinek · Seattle, Washington
Research Focus
Dr. David J. Marcinek's lab at the University of Washington focuses on understanding how aging affects mitochondria, which are crucial for energy production in our cells. By studying changes in mitochondrial function and their impact on heart and muscle health, the lab aims to develop interventions that could improve quality of life for older adults. Current projects investigate the role of specific protein interactions in aging and the effects of natural supplements like urolithin A on cardiac function.
mitochondriaagingcardiac functionprotein interactionsurolithin Aoxidative stresshuman healthmuscle functionmetabolism
Research Aims
3AIM 01Quantify changes in mitochondrial protein interactions in the heart and skeletal muscles with aging.
AIM 02Test the relationship between altered mitochondrial interactions and impaired metabolic functions in cardiomyocytes.
AIM 03Investigate whether the mitochondrial interactome changes observed in mice are present in human skeletal muscle during aging.
Skills the Lab Values
mass spectrometrymouse modelscell culturegene editingbiopsy techniquesmolecular biology techniquesmetabolomicsoxidative stress assaysquantitative proteomics
Output against the department
Publications220top 48% of dept.284th of 595
this lab
most publishedleast published
Citations7.0ktop 48% of dept.284th of 595
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.