Icahn School of Medicine at Mount Sinai · PharmacologyDevi Opioid Lab
Lakshmi A Devi · New York, New York
Research Focus
Dr. Lakshmi A. Devi’s lab at the Icahn School of Medicine focuses on understanding how the body's natural opioid system interacts with ketamine, a medication that can treat depression and chronic pain. By studying how ketamine affects opioid receptors and their signaling pathways, the lab aims to uncover the mechanisms behind ketamine's rapid and lasting effects. This research has the potential to lead to better treatments for conditions like opioid use disorder and pain management.
opioid receptorsketaminepain managementdepression treatmentopioid peptidesopioid signalinganesthesiaopioid use disorderneurobiology
Research Aims
3AIM 01Investigate the role of ketamine as a modulator of the endogenous opioid system.
AIM 02Characterize signaling pathways activated by opioid peptides compared to opioid drugs.
AIM 03Examine acute and long-term effects of ketamine on opioid receptor signaling.
Skills the Lab Values
cell cultureelectrophysiologycryoelectron microscopyWestern blotRNA sequencingprotein purificationanimal modelsdata analysisreceptor trafficking
Output against the department
Publications339top 21% of dept.99th of 462
this lab
most publishedleast published
Citations19ktop 19% of dept.90th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.