University of Pennsylvania · PhysiologyBaur Metabolism Lab
Joseph A. Baur · Philadelphia, Pennsylvania
Research Focus
Dr. Joseph A. Baur's lab at the University of Pennsylvania focuses on understanding how the metabolism of NAD+, a crucial molecule in cellular processes, can be manipulated to enhance health, especially in contexts of aging, obesity, and heart failure. The lab investigates the effects of NAD+ on glucose metabolism, muscle mass preservation during weight loss therapies, and the benefits of NAD+ precursor supplements. They aim to uncover the biological mechanisms that can lead to better therapeutic options for metabolic disorders.
NAD metabolismglucose homeostasismuscle hypertrophyobesity treatmentscardiac health
Research Aims
5AIM 01Investigate the effects of NAD+ availability on glucose metabolism
AIM 02Characterize the impact of NAD+ precursors on cellular health
AIM 03Examine the role of Activin Type II Receptor signaling in muscle growth
AIM 04Assess heart function improvements through NAD+ supplementation
AIM 05Develop novel strategies for weight loss that preserve lean muscle mass
Skills the Lab Values
mass spectrometrygenetic modelscellular metabolism assessmentmicrodissection techniquesanimal models of disease
Output against the department
Publications238top 23% of dept.67th of 286
this lab
most publishedleast published
Citations34ktop 6% of dept.17th of 286
this lab
most citedleast cited
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