UMCUniversity of Massachusetts Chan Medical School · Biochemistry
Munson Vesicle Lab
Mary Munson · Worcester, Massachusetts
Research Focus
Dr. Mary Munson's lab at the University of Massachusetts Medical School focuses on understanding how cells transport materials inside them using small vesicles. The research explores the proteins involved in the fusion of these vesicles with cellular membranes, which is crucial for processes like hormone release and neurotransmission. By studying specific proteins, particularly in the model organism yeast, the lab aims to uncover the molecular mechanisms of vesicle transport and its implications for various diseases.
vesicle transportmembrane fusionSNARE proteinsexocyst complexcell biologyyeast modelneurotransmissionhormone releasehuman diseases
Research Aims
5AIM 01Investigate how vesicle targeting and fusion specificity is achieved.
AIM 02Examine how the exocyst and Sec1 proteins regulate SNARE complexes.
AIM 03Explore the roles of different proteins and lipids in vesicle transport.
AIM 04Analyze the consequences of exocyst and Sec1 dysfunction in diseases.
AIM 05Develop new tools and methods for studying vesicle transport in eukaryotic cells.
Skills the Lab Values
biochemical techniquescell culturegenetic manipulationprotein purificationmicroscopybiophysical analysisRNA isolationdata interpretationyeast geneticsrecombinant DNA technology
Output against the department
Publications87bottom 19% of dept.324th of 402
this lab
most publishedleast published
Citations4.6kbottom 27% of dept.295th of 402
this lab
most citedleast cited
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