University of California-Irvine · BiologyThe Variant Impact Lab
Seyed Ali Mortazavi · Irvine, California
Research Focus
Dr. Seyed Ali Mortazavi's lab focuses on understanding the influence of genetic variants on gene expression and functionality in mouse models. By analyzing diverse mouse strains at the single-cell level, the lab aims to create a comprehensive resource that maps how these variants affect different cell types across various tissues. This research is crucial for developing better models of human diseases and for enhancing our understanding of genetics in health and complex diseases.
genomic variationsingle-cell genomicsgene expressionmouse modelsvariant impact
Research Aims
5AIM 01Identify genetic variants that influence gene expression in mouse tissues.
AIM 02Characterize variations in chromatin accessibility across different cell types.
AIM 03Map the relationship between genetic variants and cellular responses in macrophages.
AIM 04Develop a resource catalog of expression and splicing QTL across diverse mouse strains.
AIM 05Model the impacts of genetic variation on inflammation and disease susceptibility.
Skills the Lab Values
single-cell RNA sequencingATAC-seqchromatin accessibility assaysmouse handlingquantitative trait locus mapping
Output against the department
Publications389top 12% of dept.123rd of 1,033
this lab
most publishedleast published
Citations8.4ktop 46% of dept.473rd of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.