University of Florida · Biomedical EngineeringPhelps Metabolism Lab
Edward Phelps · Gainesville, Florida
Research Focus
Dr. Edward Phelps' lab focuses on understanding the mechanisms behind type 1 diabetes (T1D) by studying how metabolism and immune system interactions contribute to the impairment of insulin-producing beta cells. The research uses advanced techniques on human pancreas slices to map changes in glucose metabolism and evaluate how the immune environment affects cell function. This work aims to uncover insights that could lead to new therapeutic approaches for T1D and pre-diabetes.
type 1 diabetesbeta cell dysfunctionglucose metabolismmetabolic signalingimmune dysregulationspatial metabolomicsislet imaginginsulin secretionhuman pancreas slicestherapeutic development
Research Aims
5AIM 01Identify the bioenergetic dysfunction of beta cells in early T1D stages.
AIM 02Map molecular changes in glucose metabolism linked to T1D etiology.
AIM 03Assess the relationship between immune cell function and beta cell activity.
AIM 04Evaluate the impact of local immune microenvironments on insulin secretion.
AIM 05Develop novel imaging techniques to study islet function in real time.
Skills the Lab Values
MALDI imagingspatial proteomicslive tissue analysismouse modelscalcium imagingcell culturebiological data analysisimmunohistochemistrymetabolic assaysmulti-modal measurements
Output against the department
Publications83bottom 12% of dept.520th of 595
this lab
most publishedleast published
Citations3.7kbottom 29% of dept.423rd of 595
this lab
most citedleast cited
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