The University of Texas at Dallas · NeuroscienceChronic Pain Mechanisms Lab
Theodore J. Price · Richardson, Texas
Research Focus
Dr. Theodore Price's research lab focuses on understanding the molecular mechanisms behind chronic pain using human tissue samples. By analyzing the first neurons in the pain pathway, they aim to develop new therapeutic targets for pain management. The lab uses innovative techniques like CRISPR screening to conduct functional genomic studies, connecting molecular findings to real human pain conditions.
chronic painnociceptorsCRISPRgenomic screeningpain therapyhuman tissue analysismolecular profilingspinal cordneurobiology
Research Aims
5AIM 01Identify molecular phenotypes of human sensory neurons from chronic pain patients.
AIM 02Understand how nociceptors are activated in various chronic pain disorders.
AIM 03Map the connectome of the human pain pathway at the spinal cord level.
AIM 04Validate pain therapeutic targets using human DRG neurons.
AIM 05Develop a comprehensive understanding of pain receptor regulation in humans.
Skills the Lab Values
single-cell RNA sequencingspatial transcriptomicsCRISPR gene editingcell cultureimmunohistochemistrydata analysisneuron isolationmolecular profilingfunctional assays
Output against the department
Publications490top 12% of dept.79th of 671
this lab
most publishedleast published
Citations16ktop 25% of dept.168th of 671
this lab
most citedleast cited
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