University of Rochester · PharmacologyOrphan GPCR Research Lab
Cesare Orlandi · Rochester, New York
Research Focus
Dr. Cesare Orlandi's lab at the University of Rochester focuses on understanding orphan G Protein Coupled Receptors (GPCRs), particularly GPR156, which is important for hearing and balance. The lab aims to identify both synthetic and naturally occurring compounds that can activate these receptors. This research could lead to new treatments for hearing disorders by exploring the underlying biology of these receptors and their interactions in the nervous system.
GPCRorphan receptorssynthetic ligandsendogenous ligandshearing disordersbalance disorderscell signalingproteomicsmouse models
Research Aims
5AIM 01Identify synthetic and endogenous ligands for orphan GPCR GPR156.
AIM 02Characterize the signaling complex involving GPR156 in hair cells.
AIM 03Explore the physiological roles of orphan GPCRs in the central nervous system.
AIM 04Develop innovative cell-based assays for GPCR activity.
AIM 05Utilize mouse models to study the impact of GPR156 on hearing and balance.
Skills the Lab Values
cell culturebiochemical assaysproteomics analysisgenetic engineeringmouse geneticshigh-throughput screeningmulticomponent biosensorscloningmass spectrometry
Output against the department
Publications181top 50% of dept.229th of 462
this lab
most publishedleast published
Citations7.3ktop 49% of dept.228th of 462
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.