Icahn School of Medicine at Mount Sinai · BiologyDevelopmental Disorders and Regeneration Lab
Robert S. Krauss · New York, New York
Research Focus
Dr. Robert S. Krauss's lab conducts innovative research focused on understanding complex developmental disorders and muscle regeneration. One area of study examines holoprosencephaly, a brain malformation influenced by genetic and environmental factors, particularly looking at how prenatal alcohol exposure affects embryonic development. The lab also investigates the mechanisms of muscle stem cell quiescence and activation, seeking to leverage insights into muscle regeneration for therapeutic applications.
holoprosencephalyfetal alcohol exposuremuscle stem cellsdevelopmental geneticsquiescencecadherinsgene-environment interactionscell biologyregeneration
Research Aims
4AIM 01Explore the effects of Cdon mutations and ethanol on embryonic development in holoprosencephaly model systems.
AIM 02Investigate the role of cadherins in regulating satellite cell quiescence and activation during muscle regeneration.
AIM 03Characterize the cellular mechanisms by which prenatal alcohol exposure contributes to developmental defects in the brain and face.
AIM 04Determine the cytoskeletal dynamics involved in satellite cell activation using advanced imaging techniques.
Skills the Lab Values
conditional mutagenesisin situ hybridizationqRT-PCRsingle myofiber preparationlive cell imagingmouse modelscell culturetranscriptomic analysissignal transduction analysis
Output against the department
Publications151top 45% of dept.463rd of 1,033
this lab
most publishedleast published
Citations5.3kbottom 39% of dept.627th of 1,033
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.