University of Virginia-Main Campus · BiochemistryEgelman Helices Lab
Edward H. Egelman · Charlottesville, Virginia
Research Focus
Professor Edward H. Egelman's lab at the University of Virginia focuses on understanding the structures of various helical proteins and nucleoprotein polymers using advanced cryo-electron microscopy techniques. The lab studies a range of biological materials, from pathogenic bacterial filaments involved in diseases to viruses that infect extremophiles. Their research not only aims to elucidate fundamental aspects of these structures but also explores potential biomedical applications related to human health.
Cryo-electron microscopyHelical polymersBacterial filamentsVirusesSelf-assemblyActinBiomedical applicationsNucleoproteins
Research Aims
5AIM 01Investigate the structures of helical protein and nucleoprotein polymers using advanced cryo-EM techniques.
AIM 02Study the biology and structure of pathogenic bacterial components related to diseases like meningitis.
AIM 03Explore the self-assembly properties of small molecules and peptides that form tubes and filaments.
AIM 04Conduct research on actin to understand the conservation of its sequence across species.
AIM 05Develop general methods for analyzing helical polymers applicable to diverse biological systems.
Skills the Lab Values
Cryo-electron microscopyProtein purificationPolymer assembly techniquesBioinformaticsStructural biology analysisMicroscopy techniquesData visualizationComputer software usageMolecular modeling
Output against the department
Publications617top 6% of dept.24th of 402
this lab
most publishedleast published
Citations26ktop 14% of dept.58th of 402
this lab
most citedleast cited
Career totals from OpenAlex, compared against labs that share a department. A department spans everything from one paper to tens of thousands, so bar heights are on a log scale — otherwise the largest lab would flatten every other bar to a line.